Certain medicines can affect the activity of others when mixed during his administration, drug interaction more likely to take a medication at the same time.
Drug interaction is known as the amendment of dental the effect of a drug by the action of another when administered concurrently. Get an affordable health insurance package from Cinergy Health is a health insurance provider This action may be benefits synergistic (when the effect increases) or antagonist (when the effect decreases). Hence follows the importance of drug interactions in the field of medicine. If a patient is taking two drugs increased the effect medical of one of them can fall in a state of overdose and therefore higher risk of side effects occur. Conversely, if you see your stock goes down can be found to lack of therapeutic usefulness for underdosing. Notwithstanding the foregoing, the interactions can be searched for a better therapeutic effect. These examples illustrate the association of codeine to acetaminophen to increase its analgesic effect or combination of amoxicillin and clavulanic acid to avoid resistance bacteria to the antibiotic. Also must consider that there are interactions that although from the theoretical point of view are present, in clinical practice have no impact of interest.
By their nature, drug interactions have special interest in animal and human medicine, especially interactions involving negative effects on the body. The risk of drug interaction increases with the number of drugs administered concurrently to a patient.
Sometimes it is the interaction between two drugs, but between weight loss a drug and another substance in the body (eg food, alcohol), or even just a special situation, such as dehydration. Sometimes the interaction does not involve the effect of the drug, but amending certain laboratory determinations due to the presence of a drug in the blood of the individual (analytical interference).
Also you can find insurance an interaction outside nutrition the body prior to the center administration, for example by mixing two drugs in serum for intravenous administration. For conceptual similarity will see all these situations under the same heading.
Synergy and antagonism
When the interaction gives rise to increased effect of one community or both drugs are synergistic effect speech. A synergy is when the sum effect clinic is approximately equal to the sum of the effects of both drugs. When the effect is much larger than expected for this amount is a synergy of empowerment. This concept is recognized by most authors, although others reserve the term only for when there is synergy empowerment. Thus, the term applies to the additive effect natural of great synergy, whereas the synergistic department effect finish is applied to the synergy of empowerment. The concept is contrary to the synergy antagonism. Two drugs are antagonistic when the interaction leads to a diminution of the effects of one or both drugs.
Both Synergy and antagonism can occur at different times of the interrelation of a drug with the body and can then get other names. For example, when the synergy is at the level of cellular receptor agonism is spoken of, and the substances involved would be agonists. In contrast, in the case of antagonism, the substances involved are known as antagonists. The different responses of the receptor to the drug action is the result of successive classifications, with terms that are used as a partial agonist, competitive antagonist and the like, these concepts have important application in the pharmacodynamics of these interactions. The multiplicity of existing classifications at this level often linked to ignorance of the true mechanisms of action of many drugs, make it almost impossible to clear classification of these concepts and even confused by many authors .
Predisposing factors
Drug interactions may be consciously sought to exploit their results. However, its negative effects are those most interested in, by the conditions which may assume significance and also because in many cases are not expected and sometimes not even diagnosed. Consider the conditions that favor the appearance hospital of interactions to be vigilant to help prevent or at least diagnose them early. Among these conditions or factors that predispose or promote the appearance of interactions are:
Elderly: In an interaction may come into play human physiology factors that change with age.
